Pareto D, Vidal P, Alberich M, Lopez C, Auger C, Tintoré M, et al.. Prediction of a second clinical event in CIS patients by combining lesion and brain features. In Congress of the European Comitee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2019). 2019.


Prediction of a second clinical event in clinically isolated syndrome (CIS) patients, leading to clinically definite multiple sclerosis (CDMS), is still a matter of investigation. The aim of the current study was to predict conversion to CDMS after a first attack, by means of a machine-learning approach and MRI-derived brain features. For that purpose, lesion-based features (volume and distribution within brain lobes) as well as cortical thickness (CT) and deep grey matter volumes (DGMV) were used. The final goal was to determine which features were more frequently found in the classification between converters and non-converters.