@inbook {bBellot19, title = {Unsupervised GRN Ensemble}, booktitle = {Sanguinetti G., Huynh-Thu V. (eds) Methods in Molecular Biology }, volume = {1883}, year = {2019}, pages = {283-302}, publisher = { Springer science, Humana Press}, organization = { Springer science, Humana Press}, address = {New York, NY}, issn = {978-1-4939-8881-5}, doi = {https://doi-org.recursos.biblioteca.upc.edu/10.1007/978-1-4939-8882-2}, author = {P. Bellot and Salembier, P. and Pham, N.C. and Meyer, P. E.} } @article {aBellot Pujalte15, title = {NetBenchmark: a bioconductor package for reproducible benchmarks of gene regulatory network inference}, journal = {BMC Bioinformatics}, volume = {16}, year = {2015}, month = {09/2015}, abstract = {

Background:
In the last decade, a great number of methods for reconstructing gene regulatory networks from expression data have been proposed. However, very few tools and datasets allow to evaluate accurately and reproducibly those methods. Hence, we propose here a new tool, able to perform a systematic, yet fully reproducible, evaluation of transcriptional network inference methods.

Results:
Our open-source and freely available Bioconductor package aggregates a large set of tools to assess the robustness of network inference algorithms against different simulators, topologies, sample sizes and noise intensities.

Conclusions:
The benchmarking framework that uses various datasets highlights the specialization of some methods toward network types and data. As a result, it is possible to identify the techniques that have broad overall performances.

}, keywords = {Benchmark, Bioconductor package, Gene expression, Gene regulation network reconstruction, Gene regulatory networks, Synthetic genetic networks}, doi = {10.1186/s12859-015-0728-4}, url = {http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0728-4}, author = {P. Bellot and Olsen, Catharina and Salembier, P. and Albert Oliveras and Meyer, P. E.} } @conference {Bell1512:Study, title = {Study of Normalization and Aggregation Approaches for Consensus Network Estimation}, booktitle = {2015 IEEE Symposium Series on Computational Intelligence: IEEE Symposium on Artificial Life (2015 IEEE ALIFE)}, year = {2015}, address = {Cape Town, South Africa}, abstract = {

Inferring gene regulatory networks from expression data is a very difficult problem that has raised the interest of the scientific community. Different algorithms have been proposed to try to solve this issue, but it has been shown that the different methods have some particular biases and strengths, and none of them is the best across all types of data and datasets. As a result, the idea of aggregating various network inferences through a consensus mechanism naturally arises. In this paper, a common framework to standardize already proposed consensus methods is presented, and based on this framework different proposals are introduced and analyzed in two different scenarios: Homogeneous and Heterogeneous. The first scenario reflects situations where the networks to be aggregated are rather similar because the are obtained with inference algorithms working on the same data, whereas the second scenario deals with very diverse networks because various sources of data are used to generate the individual networks. A procedure for combining multiple network inference algorithms is analyzed in a systematic way. The results show that there is a very significant difference between these two scenarios, and that the best way to combine networks in the Heterogeneous scenario is not the most commonly used. We show in particular that aggregation in the Heterogeneous scenario can be very beneficial if the individual networks are combined with our new proposed method ScaleLSum.

}, author = {P. Bellot and Salembier, P. and Albert Oliveras and Meyer, P. E.} } @article {cBellot Pujalte14, title = {Efficient combination of pairwise feature networks}, journal = {JMLR: Workshop and Conference Proceedings }, volume = {46}, year = {2014}, month = {10/2015}, pages = {77 - 84}, publisher = {JMLR: Workshop and Conference Proceedings}, address = {Nancy, France}, abstract = {

This paper presents a novel method for the reconstruction of a neural network connectivity using calcium fluorescence data. We introduce a fast unsupervised method to integrate different networks that reconstructs structural connectivity from neuron activity. Our method improves the state-of-the-art reconstruction method General Transfer Entropy (GTE). We are able to better eliminate indirect links, improving therefore the quality of the network via a normalization and ensemble process of GTE and three new informative features. The approach is based on a simple combination of networks, which is remarkably fast. The performance of our approach is benchmarked on simulated time series provided at the connectomics challenge and also submitted at the public competition.

}, keywords = {connectomes, elimination of indirect links, network reconstruction algorithms}, author = {P. Bellot and Meyer, P. E.} }