@article {aCumplido-Mayoral,
	title = {The mediating role of neuroimaging-derived biological brain age between risk factors for dementia and cognitive decline in middle/late-aged asymptomatic individuals: a cohort study},
	journal = {The Lancet Healthy Longevity},
	year = {Submitted},
	author = {Irene Cumplido-Mayoral and Anna Brugulat-Serra and Gonzalo S{\'a}nchez-Benavides and Jose Luis Molinuevo and Marc Suarez-Calvet and Ver{\'o}nica Vilaplana and Juan Domingo Gispert}
}
@article {aCumplido-Mayoral22,
	title = {Biological Brain Age Prediction Using Machine Learning on Structural Neuroimaging Data: Multi-Cohort Validation Against  Biomarkers of Alzheimer{\textquoteright}s Disease and Neurodegeneration stratified by sex},
	journal = {eLife},
	volume = {12},
	year = {2023},
	month = {04/2023},
	abstract = {<p><span style="color: $\#$222222; font-family: Arial, sans-serif; font-size: 13px;">Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer9s disease (AD), but its validation against markers of neurodegeneration and AD is lacking. Here, imaging-derived measures from the UK Biobank dataset (N=22,661) were used to predict brain-age in 2,314 cognitively unimpaired (CU) individuals at higher risk of AD and mild cognitive impaired (MCI) patients from four independent cohorts with available biomarker data: ALFA+, ADNI, EPAD and OASIS. Brain-age delta was associated with abnormal amyloid-β, more advanced stages (AT) of AD pathology and APOE-ε4 status. Brain-age delta was positively associated with plasma neurofilament light, a marker of neurodegeneration, and sex differences in the brain effects of this marker were found. These results validate brain-age delta as a non-invasive marker of biological brain aging related to markers of AD and neurodegeneration.</span></p>},
	issn = {2050-084X},
	doi = {https://doi.org/10.7554/eLife.81067},
	author = {Irene Cumplido-Mayoral and Marina Garc{\'\i}a-Prat and Gregory Operto and Carles Falcon and Mahnaz Shekari and Raffaele Cacciaglia and Marta Mila-Aloma and Luigi Lorenzini and Carolina Minguillon and Jose Luis Molinuevo and Marc Suarez-Calvet and Ver{\'o}nica Vilaplana and Juan Domingo Gispert}
}
