@conference {cCumplido-Mayoral22, title = {Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer{\textquoteright}s disease and neurodegeneration stratified by sex}, booktitle = {15th Clinical Trials on Alzheimer{\textquoteright}s Disease Conference (CTAD)}, year = {2022}, month = {11/2022}, address = {San Francisco, USA}, author = {Irene Cumplido-Mayoral and Marta Mila-Aloma and Luigi Lorenzini and Alle Meije Wink and H. Mutsaerts and Sven Haller and Ga{\"e}l Chetelat and Frederik Barkhof and Marc Suarez-Calvet and Ver{\'o}nica Vilaplana and Juan D. Gispert} } @conference {cMayoral21b, title = {Prediction of amyloid pathology in cognitively unimpaired individuals using structural MRI}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2021}, month = {07/2021}, author = {Irene Cumplido-Mayoral and Silvia Ingala and Luigi Lorenzini and Alle Meije Wink and Sven Haller and Jose Luis Molinuevo and Robin Wolz and Alessandro Palombit and Adam J Schwarz and Ga{\"e}l Chetelat and Pierre Payoux and Pablo Martinez-Lage and Giovanni Frisoni and Nick C Fox and Craig W Ritchie and Joanna M Wardlaw and Adam Waldman and Frederik Barkhof and Ver{\'o}nica Vilaplana and Juan D. Gispert} } @article {aKuijf, title = {Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities; Results of the WMH Segmentation Challenge}, journal = {IEEE Transactions on Medical Imaging}, year = {2019}, month = {03/2019}, abstract = {

Quantification of white matter hyperintensities (WMH) of presumed vascular origin is of key\ importance in many neurological research studies. Advanced\ measurements are obtained from manual segmentations on brain\ MR images, which is a laborious procedure. Automatic WMH\ segmentation methods exist, but a standardized comparison of\ such methods is lacking. We organized a scientific challenge, in\ which developers could evaluate their method on a standardized\ multi-center/-scanner image dataset, giving an objective comparison:\ the WMH Segmentation Challenge (http://wmh.isi.uu.nl/).\ Sixty T1+FLAIR images from three MR scanners were released\ with manual WMH segmentations. A secret test set of 110\ images from five MR scanners was used for evaluation. Methods\ had to be containerized and submitted to the challenge organizers.Five evaluation metrics were used to rank the methods:\ (1) Dice Similarity Coefficient, (2) modified Hausdorff distance\ (95th percentile), (3) absolute percentage volume difference, (4)\ sensitivity for detecting individual lesions, and (5) F1-score for\ individual lesions. Additionally, methods were ranked on their\ inter-scanner robustness.\ Twenty participants submitted their method for evaluation.\ This paper provides a detailed analysis of the results. In brief,there is a cluster of four methods that rank significantly better\ than the other methods. There is one clear winner, which also\ has the best inter-scanner robustness.\ The challenge remains open for future submissions and provides\ a public platform for method evaluation.

}, keywords = {brain, Evaluation and performance, Magnetic resonance imaging (MRI), segmentation}, issn = {0278-0062}, doi = {10.1109/TMI.2019.2905770}, author = {Hugo Kuijf and Matthijs Biesbroek and Jeroen de Bresser and Rutger Heinen and Simon Andermatt and Mariana Bento and Matt Berseth and Mikhail Belyaev and Jorge Cardoso and Adri{\`a} Casamitjana and Louis Collins and Mahsa Dadar and Achileas Georgiou and Mohsen Ghafoorian and Dakai Jin and April Khademi and Jesse Knight and Hongwei Li and Xavier Llado and Miguel Luna and Qaiser Mahmood and Richard McKinley and Alireza Mehrtash and Sebastien Ourselin and Bo-yong Park and Hyunkin Park and Sang Hyun Park and Simon Pezold and Elodie Puybareau and Leticia Rittner and Carole Sudre and Sergi Valverde and Ver{\'o}nica Vilaplana and Rolan Wiest and Yongchao Xu and Ziyue Xu and Guodong Zeng and Jianguo Zhang and Guoyan Zheng and Christoper Chen and Wiesje van der Flier and Frederik Barkhof and Max Viergever and Geert Jan Biessels} }