@conference {cCasamitjana19, title = {Detection of Amyloid Positive Cognitively unimpaired individuals using voxel-based machine learning on structural longitudinal brain MRI}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2019}, month = {07/2019}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjana19, title = {Detection of Amyloid-Positive Cognitively Unimpaired Individuals Using Voxel-Based Machine Learning on Structural Longitudinal Brain MRI}, journal = {Alzheimer{\textquoteright}s \& Dementia}, volume = {15}, year = {2019}, month = {07/2019}, chapter = {752}, abstract = {

Magnetic resonance imaging (MRI) has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that constitutes what has been established as the {\textquoteleft}AD signature{\textquoteright}. To what extent MRI can detect amyloid-related cerebral changes from structural MRI in unimpaired individuals is still an area open for exploration.

}, issn = {1552-5260}, doi = {10.1016/j.jalz.2019.06.2796}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @conference {cPetrone, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2018}, month = {07/2018}, address = {Chicago, USA}, abstract = {

In the last decade, magnetic resonance imaging has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that conform what has been established as the AD signature. To which extent MRI can detect structural changes at the preclinical asymptomatic stage of AD - the preclinical AD signature- is still an area open for exploration. Our work supports the idea that there are brain volumetric changes specific to preclinical AD subjects and defines the preclinical AD signature based on longitudinal data. While some regions show a pattern of atrophy that overlaps with the AD signature, other specific regions exhibit changes that are unique to this early asymptomatic AD stage.

}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aPetrone18, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature.}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {14}, year = {2018}, month = {07/2018}, pages = {P1235}, doi = {10.1016/j.jalz.2018.06.1737}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjana18, title = { Projection to Latent Spaces Disentangles Specific Cerebral Morphometric Patterns Associated to Aging and Preclinical AD}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association }, volume = {14}, year = {2018}, month = {07/2018}, pages = {P869-P870}, doi = {10.1016/j.jalz.2018.06.1111}, author = {Adri{\`a} Casamitjana and P. Petrone and M. Artigues and J.L. Molinuevo and J.D. Gispert and Ver{\'o}nica Vilaplana} } @conference {cCasamitjanab, title = {Projection to Latent Spaces Disentangles Specific Cerebral Morphometric Patterns Associated to Aging and Preclinical AD}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2018}, month = {07/2018}, address = {Chicago, USA}, abstract = {

Partial Least Squares (PLS) is a mathematical technique that relates two sets of observable variables by means of a few latent explanatory factors. The aim of this study is to use PLS to discover the associations between CSF biomarkers and structural brain imaging in preclinical AD and to disentangle their specific contribution from confounding demographic factors.PLS is able to disentangle the cerebral morphometric patterns associated to preclinical AD stages from other demographic factors. Results with both cortical thickness and volumetric data present significant overlap, thus showing the robustness of this approach. Interestingly, volumetric data showed more significant correlations with CSF Abeta than cortical thickness.

}, author = {Adri{\`a} Casamitjana and P. Petrone and M. Artigues and J.L. Molinuevo and J.D. Gispert and Ver{\'o}nica Vilaplana} } @conference {cPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, booktitle = {Alzheimer{\textquoteright}s Association International Conference, London, 2017}, year = {2017}, month = {07/2017}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and A. Tucholka and C. Falcon and R. Cacciaglia and G. Operto and S. Skouras and J.L. Molinuevo and J.D. Gispert} } @article {aPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {13}, year = {2017}, month = {07/2017}, pages = {P1245}, doi = {10.1016/j.jalz.2017.07.457}, url = {https://doi.org/10.1016/j.jalz.2017.07.457}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and D. Sanchez-Escobedo and A. Tucholka and R. Cacciaglia and G. Operto and S. Skouras and C. Falcon and J.L. Molinuevo and J.D. Gispert} }