@article {aCasamitjanab, title = {NeAT: a nonlinear analysis toolbox for neuroimaging}, journal = {Neuroinformatics}, year = {2020}, month = {03/2020}, abstract = {

NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. NeAT provides a wide range of statistical and machine learning non-linear methods for model estimation, several metrics based on curve fitting and complexity for model inference and a graphical user interface (GUI) for visualization of results. We illustrate its usefulness on two study cases where non-linear effects have been previously established. Firstly, we study the nonlinear effects of Alzheimer{\textquoteright}s disease on brain morphology (volume and cortical thickness). Secondly, we analyze the effect of the apolipoprotein APOE-ε4 genotype on brain aging and its interaction with age. NeAT is fully documented and publicly distributed at https://imatge-upc.github.io/neat-tool/.

}, keywords = {Alzheimer{\textquoteright}s disease, APOE, GAM, GLM, inference, neuroimaging, nonlinear., SVR}, doi = {10.1007/s12021-020-09456-w}, url = {https://link.springer.com/article/10.1007/s12021-020-09456-w}, author = {Adri{\`a} Casamitjana and Ver{\'o}nica Vilaplana and Santi Puch and Asier Aduriz and Carlos Lopez and G. Operto and R. Cacciaglia and C. Falcon and J.L. Molinuevo and Juan D. Gispert} } @conference {cCasamitjana19, title = {Detection of Amyloid Positive Cognitively unimpaired individuals using voxel-based machine learning on structural longitudinal brain MRI}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2019}, month = {07/2019}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjana19, title = {Detection of Amyloid-Positive Cognitively Unimpaired Individuals Using Voxel-Based Machine Learning on Structural Longitudinal Brain MRI}, journal = {Alzheimer{\textquoteright}s \& Dementia}, volume = {15}, year = {2019}, month = {07/2019}, chapter = {752}, abstract = {

Magnetic resonance imaging (MRI) has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that constitutes what has been established as the {\textquoteleft}AD signature{\textquoteright}. To what extent MRI can detect amyloid-related cerebral changes from structural MRI in unimpaired individuals is still an area open for exploration.

}, issn = {1552-5260}, doi = {10.1016/j.jalz.2019.06.2796}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjanaa, title = {Shared latent structures between imaging features and biomarkers in early stages of Alzheimer{\textquoteright}s disease: a predictive study}, journal = {IEEE Journal of Biomedical and Health Informatics}, year = {2019}, month = {08/2019}, abstract = {

Magnetic resonance imaging (MRI) provides high resolution brain morphological information and is used as a biomarker in neurodegenerative diseases. Population studies of brain morphology often seek to identify pathological structural changes related to different diagnostic categories (e.g: controls, mild cognitive impairment or dementia) which normally describe highly heterogeneous groups with a single categorical variable. Instead, multiple biomarkers are used as a proxy for pathology and are more powerful in capturing structural variability. Hence, using the joint modeling of brain morphology and biomarkers, we aim at describing structural changes related to any brain condition by means of few underlying processes. In this regard, we use a multivariate approach based on Projection to Latent Structures in its regression variant (PLSR) to study structural changes related to aging and AD pathology. MRI volumetric and cortical thickness measurements are used for brain morphology and cerebrospinal fluid (CSF) biomarkers (t-tau, p-tau and amyloid-beta) are used as a proxy for AD pathology. By relating both sets of measurements, PLSR finds a low-dimensional latent space describing AD pathological effects on brain structure. The proposed framework allows to separately model aging effects on brain morphology as a confounder variable orthogonal to the pathological effect. The predictive power of the associated latent spaces (i.e. the capacity of predicting biomarker values) is assessed in a cross-validation framework.\ 

}, keywords = {CSF biomarkers, Latent model, MRI, PLS, preclinical AD}, doi = {10.1109/JBHI.2019.2932565}, author = {Adri{\`a} Casamitjana and Paula Petrone and J.L. Molinuevo and Juan D. Gispert and Ver{\'o}nica Vilaplana} } @conference {cPetrone, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2018}, month = {07/2018}, address = {Chicago, USA}, abstract = {

In the last decade, magnetic resonance imaging has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that conform what has been established as the AD signature. To which extent MRI can detect structural changes at the preclinical asymptomatic stage of AD - the preclinical AD signature- is still an area open for exploration. Our work supports the idea that there are brain volumetric changes specific to preclinical AD subjects and defines the preclinical AD signature based on longitudinal data. While some regions show a pattern of atrophy that overlaps with the AD signature, other specific regions exhibit changes that are unique to this early asymptomatic AD stage.

}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aPetrone18, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature.}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {14}, year = {2018}, month = {07/2018}, pages = {P1235}, doi = {10.1016/j.jalz.2018.06.1737}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjana18, title = { Projection to Latent Spaces Disentangles Specific Cerebral Morphometric Patterns Associated to Aging and Preclinical AD}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association }, volume = {14}, year = {2018}, month = {07/2018}, pages = {P869-P870}, doi = {10.1016/j.jalz.2018.06.1111}, author = {Adri{\`a} Casamitjana and P. Petrone and M. Artigues and J.L. Molinuevo and J.D. Gispert and Ver{\'o}nica Vilaplana} } @conference {cCasamitjanab, title = {Projection to Latent Spaces Disentangles Specific Cerebral Morphometric Patterns Associated to Aging and Preclinical AD}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2018}, month = {07/2018}, address = {Chicago, USA}, abstract = {

Partial Least Squares (PLS) is a mathematical technique that relates two sets of observable variables by means of a few latent explanatory factors. The aim of this study is to use PLS to discover the associations between CSF biomarkers and structural brain imaging in preclinical AD and to disentangle their specific contribution from confounding demographic factors.PLS is able to disentangle the cerebral morphometric patterns associated to preclinical AD stages from other demographic factors. Results with both cortical thickness and volumetric data present significant overlap, thus showing the robustness of this approach. Interestingly, volumetric data showed more significant correlations with CSF Abeta than cortical thickness.

}, author = {Adri{\`a} Casamitjana and P. Petrone and M. Artigues and J.L. Molinuevo and J.D. Gispert and Ver{\'o}nica Vilaplana} } @conference {cPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, booktitle = {Alzheimer{\textquoteright}s Association International Conference, London, 2017}, year = {2017}, month = {07/2017}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and A. Tucholka and C. Falcon and R. Cacciaglia and G. Operto and S. Skouras and J.L. Molinuevo and J.D. Gispert} } @article {aPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {13}, year = {2017}, month = {07/2017}, pages = {P1245}, doi = {10.1016/j.jalz.2017.07.457}, url = {https://doi.org/10.1016/j.jalz.2017.07.457}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and D. Sanchez-Escobedo and A. Tucholka and R. Cacciaglia and G. Operto and S. Skouras and C. Falcon and J.L. Molinuevo and J.D. Gispert} }