@article {aCasamitjanab, title = {NeAT: a nonlinear analysis toolbox for neuroimaging}, journal = {Neuroinformatics}, year = {2020}, month = {03/2020}, abstract = {

NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. NeAT provides a wide range of statistical and machine learning non-linear methods for model estimation, several metrics based on curve fitting and complexity for model inference and a graphical user interface (GUI) for visualization of results. We illustrate its usefulness on two study cases where non-linear effects have been previously established. Firstly, we study the nonlinear effects of Alzheimer{\textquoteright}s disease on brain morphology (volume and cortical thickness). Secondly, we analyze the effect of the apolipoprotein APOE-ε4 genotype on brain aging and its interaction with age. NeAT is fully documented and publicly distributed at https://imatge-upc.github.io/neat-tool/.

}, keywords = {Alzheimer{\textquoteright}s disease, APOE, GAM, GLM, inference, neuroimaging, nonlinear., SVR}, doi = {10.1007/s12021-020-09456-w}, url = {https://link.springer.com/article/10.1007/s12021-020-09456-w}, author = {Adri{\`a} Casamitjana and Ver{\'o}nica Vilaplana and Santi Puch and Asier Aduriz and Carlos Lopez and G. Operto and R. Cacciaglia and C. Falcon and J.L. Molinuevo and Juan D. Gispert} } @conference {cCasamitjana19, title = {Detection of Amyloid Positive Cognitively unimpaired individuals using voxel-based machine learning on structural longitudinal brain MRI}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2019}, month = {07/2019}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aCasamitjana19, title = {Detection of Amyloid-Positive Cognitively Unimpaired Individuals Using Voxel-Based Machine Learning on Structural Longitudinal Brain MRI}, journal = {Alzheimer{\textquoteright}s \& Dementia}, volume = {15}, year = {2019}, month = {07/2019}, chapter = {752}, abstract = {

Magnetic resonance imaging (MRI) has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that constitutes what has been established as the {\textquoteleft}AD signature{\textquoteright}. To what extent MRI can detect amyloid-related cerebral changes from structural MRI in unimpaired individuals is still an area open for exploration.

}, issn = {1552-5260}, doi = {10.1016/j.jalz.2019.06.2796}, author = {Adri{\`a} Casamitjana and P. Petrone and C. Falcon and M. Artigues and G. Operto and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @conference {cPetrone, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature}, booktitle = {Alzheimer{\textquoteright}s Association International Conference}, year = {2018}, month = {07/2018}, address = {Chicago, USA}, abstract = {

In the last decade, magnetic resonance imaging has unveiled specific AD alterations at different stages of the AD pathophysiologic continuum that conform what has been established as the AD signature. To which extent MRI can detect structural changes at the preclinical asymptomatic stage of AD - the preclinical AD signature- is still an area open for exploration. Our work supports the idea that there are brain volumetric changes specific to preclinical AD subjects and defines the preclinical AD signature based on longitudinal data. While some regions show a pattern of atrophy that overlaps with the AD signature, other specific regions exhibit changes that are unique to this early asymptomatic AD stage.

}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and R. Cacciaglia and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @article {aPetrone18, title = {Characteristic Brain Volumetric Changes in the AD Preclinical Signature.}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {14}, year = {2018}, month = {07/2018}, pages = {P1235}, doi = {10.1016/j.jalz.2018.06.1737}, author = {P. Petrone and Adri{\`a} Casamitjana and C. Falcon and M. Artigues and G. Operto and S. Skouras and J.L. Molinuevo and Ver{\'o}nica Vilaplana and J.D. Gispert} } @conference {cPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, booktitle = {Alzheimer{\textquoteright}s Association International Conference, London, 2017}, year = {2017}, month = {07/2017}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and A. Tucholka and C. Falcon and R. Cacciaglia and G. Operto and S. Skouras and J.L. Molinuevo and J.D. Gispert} } @article {aPetrone17, title = {Magnetic Resonance Imaging as a valuable tool for Alzheimer{\textquoteright}s disease screening}, journal = {Alzheimer{\textquoteright}s \& Dementia: The Journal of the Alzheimer{\textquoteright}s Association}, volume = {13}, year = {2017}, month = {07/2017}, pages = {P1245}, doi = {10.1016/j.jalz.2017.07.457}, url = {https://doi.org/10.1016/j.jalz.2017.07.457}, author = {P. Petrone and Ver{\'o}nica Vilaplana and Adri{\`a} Casamitjana and D. Sanchez-Escobedo and A. Tucholka and R. Cacciaglia and G. Operto and S. Skouras and C. Falcon and J.L. Molinuevo and J.D. Gispert} }