@article {aCasamitjanab, title = {NeAT: a nonlinear analysis toolbox for neuroimaging}, journal = {Neuroinformatics}, year = {2020}, month = {03/2020}, abstract = {

NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. NeAT provides a wide range of statistical and machine learning non-linear methods for model estimation, several metrics based on curve fitting and complexity for model inference and a graphical user interface (GUI) for visualization of results. We illustrate its usefulness on two study cases where non-linear effects have been previously established. Firstly, we study the nonlinear effects of Alzheimer{\textquoteright}s disease on brain morphology (volume and cortical thickness). Secondly, we analyze the effect of the apolipoprotein APOE-ε4 genotype on brain aging and its interaction with age. NeAT is fully documented and publicly distributed at https://imatge-upc.github.io/neat-tool/.

}, keywords = {Alzheimer{\textquoteright}s disease, APOE, GAM, GLM, inference, neuroimaging, nonlinear., SVR}, doi = {10.1007/s12021-020-09456-w}, url = {https://link.springer.com/article/10.1007/s12021-020-09456-w}, author = {Adri{\`a} Casamitjana and Ver{\'o}nica Vilaplana and Santi Puch and Asier Aduriz and Carlos Lopez and G. Operto and R. Cacciaglia and C. Falcon and J.L. Molinuevo and Juan D. Gispert} } @mastersthesis {xPuch16, title = {Nonlinear analysis toolbox for neurodegenerative diseases and aging}, year = {2016}, abstract = {

Advisor: Ver{\'o}nica Vilaplana

Studies: Bachelor degree in Science and Telecommunication Technologies Engineering at\ Telecom BCN-ETSETB\ from the Technical University of Catalonia (UPC)

Neurodegenerative diseases impose substantial public health burdens on populations
throughout the world. Alzheimer{\textquoteright}s disease is among the major neurodegenerative diseases,
and its causes and treatment are still unknown. Researchers around the world are conducting
large data-driven studies in order to unveil the causes and biological mechanisms of such
diseases, and for that reason automatic tools that allow to uncover statistically signi cant
ndings are needed.
To address this problem we present in this thesis a software toolbox that provides the
tools to analyze the linear and nonlinear dynamics of gray-matter and study the statistical
signi cance of such dynamics at the voxel level. The toolbox features various tting methods
and t evaluation metrics, an automatic hyperparameters look-up algorithm and several
visualization and comparison tools.
All the features provided in this toolbox were tested in two real problems provided by
the Pasqual Maragall Foundation, and it yielded results that were validated by the ndings
in the original studies.

}, author = {Santi Puch}, editor = {Ver{\'o}nica Vilaplana} }